Sulfolactate sulfo-lyase

Sulfolactate sulfo-lyase
Identifiers
EC number	4.4.1.24
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a sulfolactate sulfo-lyase (EC 4.4.1.24, Suy, SuyAB, 3-sulfolactate bisulfite-lyase, sulfolactate sulfo-lyase) is an enzyme that catalyzes the chemical reaction

3-sulfolactate $\rightleftharpoons$ pyruvate + bisulfite

Hence, this enzyme has one substrate, 3-sulfolactate, and two products, pyruvate and bisulfite.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is 3-sulfolactate bisulfite-lyase (pyruvate-forming). Other names in common use include Suy, SuyAB, and 3-sulfolactate bisulfite-lyase.^[1][2][3]

References

1. Graham, D.E. and White, R.H. (2002). "Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics". Nat. Prod. Rep. 19: 133–147. doi:10.1039/b103714p. PMID 12013276.
2. Rein, U., Gueta, R., Denger, K., Ruff, J., Hollemeyer, K. and Cook, A.M. (2005). "Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA". Microbiology 151: 737–747. doi:10.1099/mic.0.27548-0. PMID 15758220.
3. Denger, K. and Cook, A.M. (2010). "Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase". Microbiology 156 (Pt 3): 967–974. doi:10.1099/mic.0.034736-0. PMID 20007648.