(6-4)DNA photolyase

(6-4)DNA photolyase
Identifiers
EC number 4.1.99.13
CAS number 37290-70-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(6-4)DNA photolyase (EC 4.1.99.13, DNA photolyase, H64PRH, NF-10, phr (6-4), PL-(6-4), OtCPF1, (6-4) PHR, At64PHR) is an enzyme with systematic name (6-4) photoproduct pyrimidine-lyase.[1][2] This enzyme catalyses the following chemical reaction

(6-4) photoproduct (in DNA) \rightleftharpoons 2 pyrimidine residues (in DNA)

This enzyme is a flavoprotein.

References

  1. Hitomi, K., DiTacchio, L., Arvai, A.S., Yamamoto, J., Kim, S.T., Todo, T., Tainer, J.A., Iwai, S., Panda, S. and Getzoff, E.D. (2009). "Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes". Proc. Natl. Acad. Sci. USA 106: 6962–6967. doi:10.1073/pnas.0809180106. PMID 19359474.
  2. Schleicher, E., Hitomi, K., Kay, C.W., Getzoff, E.D., Todo, T. and Weber, S. (2007). "Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase". J. Biol. Chem. 282: 4738–4747. doi:10.1074/jbc.m604734200. PMID 17164245.

External links

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