(6-4)DNA photolyase
(6-4)DNA photolyase (EC 4.1.99.13, DNA photolyase, H64PRH, NF-10, phr (6-4), PL-(6-4), OtCPF1, (6-4) PHR, At64PHR) is an enzyme with systematic name (6-4) photoproduct pyrimidine-lyase.[1][2] This enzyme catalyses the following chemical reaction
- (6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
This enzyme is a flavoprotein.
References
- ↑ Hitomi, K., DiTacchio, L., Arvai, A.S., Yamamoto, J., Kim, S.T., Todo, T., Tainer, J.A., Iwai, S., Panda, S. and Getzoff, E.D. (2009). "Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes". Proc. Natl. Acad. Sci. USA 106: 6962–6967. doi:10.1073/pnas.0809180106. PMID 19359474.
- ↑ Schleicher, E., Hitomi, K., Kay, C.W., Getzoff, E.D., Todo, T. and Weber, S. (2007). "Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase". J. Biol. Chem. 282: 4738–4747. doi:10.1074/jbc.m604734200. PMID 17164245.
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