(R)-2-haloacid dehalogenase

Identifiers
EC number	3.8.1.9
CAS number	119345-29-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a (R)-2-haloacid dehalogenase (EC 3.8.1.9), DL-2-haloacid halidohydrolase (inversion of configuration), DL-DEXi, (R,S)-2-haloacid dehalogenase (configuration-inverting)) is an enzyme that catalyzes the chemical reaction

(R)-2-haloacid + H₂O $\rightleftharpoons$ (S)-2-hydroxyacid + halide

Thus, the two substrates of this enzyme are (R)-2-haloacid and H₂O, whereas its two products are (S)-2-hydroxyacid and halide.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is (R)-2-haloacid halidohydrolase. Other names in common use include 2-haloalkanoic acid dehalogenase[ambiguous], 2-haloalkanoid acid halidohydrolase[ambiguous], D-2-haloacid dehalogenase, and D-DEX.

References

• Smith JM, Harrison K, Colby J (1990). "Purification and characterization of D-2-haloacid dehalogenase from Pseudomonas putida strain AJ1/23". J. Gen. Microbiol. 136 (5): 881–6. doi:10.1099/00221287-136-5-881. PMID 2380688.
• Leigh JA, Skinner AJ and Cooper RA (1988). "Partial purification, stereospecificity and stoichiometry of three dehalogenases from a Rhizobium species". FEMS Microbiol. Lett. 49 (3): 353–356. doi:10.1111/j.1574-6968.1988.tb02756.x.
• M, Tsunasawa S and Esaki N (1996). "Bacterial 2-haloacid dehalogenases: Structures and catalytic properties". Pure Appl. Chem. 68 (11): 2097–2103. doi:10.1351/pac199668112097.