1,2,4-Triazole

1,2,4-Triazole
Names
IUPAC name
1H-1,2,4-triazole
Other names
1,2,4-triazole pyrrodiazole
Identifiers
288-88-0 YesY
ChEBI CHEBI:46077 YesY
ChEMBL ChEMBL15571 YesY
ChemSpider 8900 YesY
Jmol interactive 3D Image
PubChem 9257
Properties
C2H3N3
Molar mass 69.0654
Appearance white solid
Melting point 120 to 121
Boiling point 260
very soluble
Acidity (pKa) 10,3
Basicity (pKb) 11,8
Hazards
Flash point 140 °C (284 °F; 413 K)
Related compounds
Related compounds
1,2,3-triazole imidazole
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY verify (what is YesYN ?)
Infobox references

1,2,4-Triazole is one of a pair of isomeric chemical compounds with molecular formula C2H3N3, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. 1,2,4-Triazole is a basic aromatic heterocycle. 1,2,4-Triazole derivatives find use in a wide variety of applications, most notably as antifungals such as fluconazole and itraconazole.

1,2,4-Triazoles can be prepared using the Einhorn–Brunner reaction or the Pellizzari reaction.[1]

The ring structure appears in certain N-heterocyclic carbenes.

See also

References

  1. Potts K. T. (1961). "The Chemistry of 1,2,4-Triazoles.". Chemical Reviews 61 (2): 87–127. doi:10.1021/cr60210a001.
This article is issued from Wikipedia - version of the Wednesday, November 18, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.