1,2,4-Triazole
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| Names | |||
|---|---|---|---|
| IUPAC name
1H-1,2,4-triazole | |||
| Other names
1,2,4-triazole pyrrodiazole | |||
| Identifiers | |||
288-88-0  | |||
| ChEBI | CHEBI:46077 | ||
| ChEMBL | ChEMBL15571 | ||
| ChemSpider | 8900 | ||
| Jmol interactive 3D | Image | ||
| PubChem | 9257 | ||
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| Properties | |||
| C2H3N3 | |||
| Molar mass | 69.0654 | ||
| Appearance | white solid | ||
| Melting point | 120 to 121 | ||
| Boiling point | 260 | ||
| very soluble | |||
| Acidity (pKa) | 10,3 | ||
| Basicity (pKb) | 11,8 | ||
| Hazards | |||
| Flash point | 140 °C (284 °F; 413 K) | ||
| Related compounds | |||
| Related compounds |
1,2,3-triazole imidazole | ||
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |||
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| Infobox references | |||
1,2,4-Triazole is one of a pair of isomeric chemical compounds with molecular formula C2H3N3, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. 1,2,4-Triazole is a basic aromatic heterocycle. 1,2,4-Triazole derivatives find use in a wide variety of applications, most notably as antifungals such as fluconazole and itraconazole.
1,2,4-Triazoles can be prepared using the Einhorn–Brunner reaction or the Pellizzari reaction.[1]
The ring structure appears in certain N-heterocyclic carbenes.
See also
- Used in the preparation of Rizatriptan.
References
- ↑ Potts K. T. (1961). "The Chemistry of 1,2,4-Triazoles.". Chemical Reviews 61 (2): 87–127. doi:10.1021/cr60210a001.
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