1,2-dehydroreticulinium reductase (NADPH)

1,2-dehydroreticulinium reductase (NADPH)
Identifiers
EC number	1.5.1.27
CAS number	130590-58-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 1,2-dehydroreticulinium reductase (NADPH) (EC 1.5.1.27) is an enzyme that catalyzes the chemical reaction

(R)-reticuline + NADP⁺ $\rightleftharpoons$ 1,2-dehydroreticulinium + NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-reticuline and NADP⁺, whereas its 3 products are 1,2-dehydroreticulinium, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-reticuline:NADP+ oxidoreductase. This enzyme is also called 1,2-dehydroreticulinium ion reductase. This enzyme participates in alkaloid biosynthesis i.

References

• De-Eknamkul, Wanchai; Zenk, Meinhart H. (1992). "Purification and properties of 1,2-dehydroreticulinium reductase from Papaver somniferum seedlings". Phytochemistry 31 (3): 813–821. doi:10.1016/0031-9422(92)80020-F.