11-Dehydrothromboxane B2

11-Dehydrothromboxane B2
Names
IUPAC name
(Z)-7-[(2R,3S,4S)-4-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-6-oxo-tetrahydropyran-3-yl]hept-5-enoic acid
Other names
11-Dehydro-thromboxane B2
Identifiers
67910-12-7 N
ChEBI CHEBI:28667 YesY
ChemSpider 4444414 YesY
4484
Jmol interactive 3D Image
KEGG C05964 YesY
PubChem 5280891
Properties
C20H32O6
Molar mass 368.46
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

11-Dehydrothromboxane B2 (or 11-dehydro-TXB2) is produced from the breakdown of thromboxane A2. It is released by activated platelets and urine levels of 11-dehydro-TXB2 can be used to monitor the response to aspirin therapy when used to prevent heart disease[1] and in diseases where platelet activation is prominent.[2]

References

  1. Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG (2007). "A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease". Eur Heart J 28 (14): 1702–1708. doi:10.1093/eurheartj/ehm226. PMID 17569678.
  2. Catella F, Healy D, Lawson JA, FitzGerald GA (1986). "11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation". PNAS 83 (16): 5861–5865. doi:10.1073/pnas.83.16.5861. PMC 386396. PMID 3461463.
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