16S rRNA pseudouridine516 synthase

16S rRNA pseudouridine^516 synthase
Identifiers
EC number	5.4.99.19
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

16S rRNA pseudouridine⁵¹⁶ synthase (EC 5.4.99.19, 16S RNA pseudouridine⁵¹⁶ synthase, 16S PsiI⁵¹⁶ synthase, 16S RNA Psi⁵¹⁶ synthase, RNA pseudouridine synthase RsuA, RsuA, 16S RNA pseudouridine 516 synthase) is an enzyme with systematic name 16S rRNA-uridine⁵¹⁶ uracil mutase.^[1][2][3] This enzyme catalyses the following chemical reaction

16S rRNA uridine⁵¹⁶ $\rightleftharpoons$ 16S rRNA pseudouridine⁵¹⁶

The enzyme is specific for uridine⁵¹⁶ in 16S rRNA.

References

1. Wrzesinski, J., Bakin, A., Nurse, K., Lane, B.G. and Ofengand, J. (1995). "Purification, cloning, and properties of the 16S RNA pseudouridine 516 synthase from Escherichia coli". Biochemistry 34: 8904–8913. doi:10.1021/bi00027a043. PMID 7612632.
2. Conrad, J., Niu, L., Rudd, K., Lane, B.G. and Ofengand, J. (1999). "16S ribosomal RNA pseudouridine synthase RsuA of Escherichia coli: deletion, mutation of the conserved Asp¹⁰² residue, and sequence comparison among all other pseudouridine synthases". RNA 5: 751–763. doi:10.1017/s1355838299990167. PMID 10376875.
3. Sivaraman, J., Sauve, V., Larocque, R., Stura, E.A., Schrag, J.D., Cygler, M. and Matte, A. (2002). "Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP". Nat. Struct. Biol. 9: 353–358. doi:10.1038/nsb788. PMID 11953756.

External links

• 16S rRNA pseudouridine516 synthase at the US National Library of Medicine Medical Subject Headings (MeSH)