1978 East Carolina Pirates football team
      
The 1978 East Carolina Pirates football team represented the East Carolina University during the 1978 college football season.
Schedule
| Date | Opponent | Site | TV | Result | 
|---|
| September 2 | Western Carolina | Ficklen Stadium • Greenville, North Carolina |  | W 14–6 | 
| September 9 | at NC State | Raleigh, North Carolina |  | L 13–29 | 
| September 16 | at North Carolina | Chapel Hill, North Carolina |  | L 10–14 | 
| September 23 | at Southwestern Louisiana | Lafayette, Louisiana |  | W 38–9 | 
| September 30 | UT Arlington | Ficklen Stadium • Greenville, North Carolina |  | W 23–17 | 
| October 7 | at VMI | Lexington, Virginia |  | W 19–6 | 
| October 14 | at Southern Miss | Hattiesburg, Mississippi |  | L 16–17 | 
| October 21 | vs. Richmond | Norfolk, Virginia |  | W 21–14 | 
| November 4 | Appalachian State | Ficklen Stadium • Greenville, North Carolina |  | W 33–8 | 
| November 11 | William & Mary | Ficklen Stadium • Greenville, North Carolina |  | W 20–3 | 
| November 18 | Marshall | Ficklen Stadium • Greenville, North Carolina |  | W 45–0 | 
| December 16 | vs. Louisiana Tech | State Fair Stadium • Shreveport, Louisiana (Independence Bowl) |  | W 35–13 | 
| All times are in Eastern. | 
| |  | 
|---|
 |  |  | Venues |  | 
|---|
 |  |  | Bowls & rivalries |  | 
|---|
 |  |  | Culture & lore | 
 PeeDee the Pirate The Marching Pirates
 | 
|---|
 |  |  | People |  | 
|---|
 |  |  | Seasons |  | 
|---|
 |