1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase

1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase
Identifiers
EC number	2.6.1.56
CAS number	57127-19-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase (EC 2.6.1.56) is an enzyme that catalyzes the chemical reaction

1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate $\rightleftharpoons$ 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine

Thus, the two substrates of this enzyme are 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol and pyruvate, whereas its two products are 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol and L-alanine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase. Other names in common use include guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase, and L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase.

References

• Walker JB (1971). "Enzymatic reactions involved in streptomycin biosynthesis and metabolism". Lloydia. 34 (4): 363–71. PMID 4376579.
• Walker JB, Walker MS (1969). "Streptomycin biosynthesis. Transamination reactions involving inosamines and inosadiamines". Biochemistry. 8 (3): 763–70. doi:10.1021/bi00831a003. PMID 5781017.