2,4'-dihydroxyacetophenone dioxygenase

2,4'-dihydroxyacetophenone dioxygenase
Identifiers
EC number	1.13.11.41
CAS number	105503-64-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 2,4'-dihydroxyacetophenone dioxygenase (EC 1.13.11.41) is an enzyme that catalyzes the chemical reaction

2,4'-dihydroxyacetophenone + O₂ $\rightleftharpoons$ 4-hydroxybenzoate + formate

Thus, the two substrates of this enzyme are 2,4'-dihydroxyacetophenone and O₂, whereas its two products are 4-hydroxybenzoate and formate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving). This enzyme is also called (4-hydroxybenzoyl)methanol oxygenase. This enzyme participates in bisphenol a degradation.^[1]

References

1. Mayu Enya; Keiko Aoyagi; Yoshihiro Hishikawa; Azusa Yoshimura; Koichi Mitsukura; Kiyofumi Marayuma (2012). "Molecular and Catalytic Properties of 2,4′-Dihydroxyacetophenone Dioxygenase from Burkholderia sp. AZ11". Bioscience, Biotechnology, and Biochemistry 76 (3): 567–574. doi:10.1271/bbb.110867.

• Hopper DJ (1986). "Oxygenase properties of the (4-hydroxybenzoyl)methanol-cleavage enzyme from an Alcaligenes sp". Biochem. J. 239 (2): 469–72. PMC 1147303. PMID 3814084.