2-haloacid dehalogenase (configuration-retaining)

2-haloacid dehalogenase (configuration-retaining)
Identifiers
EC number	3.8.1.11
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-haloacid dehalogenase (configuration-retaining) (EC 3.8.1.11, 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL-2-haloacid dehalogenase, DL-DEXr) is an enzyme with systematic name (S)-2-haloacid dehalogenase (configuration-retaining).^[1][2] This enzyme catalyses the following chemical reaction

(1) (S)-2-haloacid + H₂O $\rightleftharpoons$ (S)-2-hydroxyacid + halide

(2) (R)-2-haloacid + H₂O $\rightleftharpoons$ (R)-2-hydroxyacid + halide

Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids.

References

1. Weightman, A.J., Weightman, A.L. and Slater, J.H. (1982). "Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas P3: evidence for two different dehalogenation mechanisms". J. Gen. Microbiol. 128 (8): 1755–1762. doi:10.1099/00221287-128-8-1755. PMID 7142958.
2. Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N. (1996). "Bacterial 2-haloacid dehalogenases: Structures and catalytic properties". Pure Appl. Chem. 68: 2097–2103. doi:10.1351/pac199668112097.

External links

• 2-haloacid dehalogenase (configuration-retaining) at the US National Library of Medicine Medical Subject Headings (MeSH)