2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase

2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase
Identifiers
EC number	3.7.1.13
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase (EC 3.7.1.13, CarC) is an enzyme with systematic name (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate acylhydrolase.^[1][2] This enzyme catalyses the following chemical reaction

(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H₂O $\rightleftharpoons$ anthranilate + (2E)-2-hydroxypenta-2,4-dienoate

This enzyme catalyses the third step in the aerobic degradation pathway of carbazole.

References

1. Nojiri, H., Taira, H., Iwata, K., Morii, K., Nam, J.W., Yoshida, T., Habe, H., Nakamura, S., Shimizu, K., Yamane, H. and Omori, T. (2003). "Purification and characterization of meta-cleavage compound hydrolase from a carbazole degrader Pseudomonas resinovorans strain CA10". Biosci. Biotechnol. Biochem. 67 (1): 36–45. doi:10.1271/bbb.67.36. PMID 12619671.
2. Riddle, R.R., Gibbs, P.R., Willson, R.C. and Benedik, M.J. (2003). "Purification and properties of 2-hydroxy-6-oxo-6-(2′-aminophenyl)hexa-2,4-dienoic acid hydrolase involved in microbial degradation of carbazole". Protein Expr. Purif. 28 (1): 182–189. doi:10.1016/S1046-5928(02)00676-9. PMID 12651123.

External links

• 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)