2-hydroxy-6-oxonona-2,4-dienedioate hydrolase

2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
Identifiers
EC number	3.7.1.14
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-hydroxy-6-oxonona-2,4-dienedioate hydrolase (EC 3.7.1.14, mhpC (gene)) is an enzyme with systematic name (2Z,4E)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase.^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

(1) (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H₂O $\rightleftharpoons$ (2Z)-2-hydroxypenta-2,4-dienoate + succinate

(2) (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H₂O $\rightleftharpoons$ (2Z)-2-hydroxypenta-2,4-dienoate + fumarate

This enzyme catalyses a step in a pathway of phenylpropanoid compounds degradation.

References

1. Burlingame, R. and Chapman, P.J. (1983). "Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli". J. Bacteriol. 155 (1): 113–121. PMC 217659. PMID 6345502.
2. Burlingame, R.P., Wyman, L. and Chapman, P.J. (1986). "Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation". J. Bacteriol. 168 (1): 55–64. PMC 213419. PMID 3531186.
3. Lam, W. W. Y and Bugg, T. D. H. (1994). "Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic clevage". J. Chem. Soc., Chem. Commun. 10 (10): 1163–1164. doi:10.1039/c39940001163.
4. Lam, W.W. and Bugg, T.D. (1997). "Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase". Biochemistry 36 (40): 12242–12251. doi:10.1021/bi971115r. PMID 9315862.
5. Ferrández, A., García, J.L. and Díaz, E. (1997). "Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12". J. Bacteriol. 179 (8): 2573–2581. PMC 179006. PMID 9098055.
6. Díaz, E., Ferrández, A. and García, J.L. (1998). "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". J. Bacteriol. 180 (11): 2915–2923. PMC 107259. PMID 9603882.

External links

• 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)