2-hydroxyethylphosphonate dioxygenase

2-hydroxyethylphosphonate dioxygenase
Identifiers
EC number	1.13.11.72
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-hydroxyethylphosphonate dioxygenase (EC 1.13.11.72, HEPD, phpD (gene)) is an enzyme with systematic name 2-hydroxyethylphosphonate:O₂ 1,2-oxidoreductase (hydroxymethylphosphonate forming).^[1][2][3] This enzyme catalyses the following chemical reaction

2-hydroxyethylphosphonate + O₂ $\rightleftharpoons$ hydroxymethylphosphonate + formate

2-hydroxyethylphosphonate dioxygenase contains non-heme-Fe(II).

References

1. Cicchillo, R.M., Zhang, H., Blodgett, J.A., Whitteck, J.T., Li, G., Nair, S.K., van der Donk, W.A. and Metcalf, W.W. (2009). "An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis". Nature 459 (7248): 871–874. doi:10.1038/nature07972. PMC 2874955. PMID 19516340.
2. Whitteck, J.T., Malova, P., Peck, S.C., Cicchillo, R.M., Hammerschmidt, F. and van der Donk, W.A. (2011). "On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase". J. Am. Chem. Soc. 133 (12): 4236–4239. doi:10.1021/ja1113326. PMC 3069692. PMID 21381767.
3. Peck, S.C., Cooke, H.A., Cicchillo, R.M., Malova, P., Hammerschmidt, F., Nair, S.K. and van der Donk, W.A. (2011). "Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase". Biochemistry 50 (30): 6598–6605. doi:10.1021/bi200804r. PMC 3143709. PMID 21711001.

External links

• 2-hydroxyethylphosphonate dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)