2-Hydroxymuconate-6-semialdehyde dehydrogenase

2-Hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.85, xylG (gene), praB (gene)) is an enzyme with systematic name (2E,4Z)-2-hydroxy-6-oxohexa-2,4-dienoate:NAD⁺ oxidoreductase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

2-hydroxymuconate-6-semialdehyde + NAD⁺ + H₂O

\rightleftharpoons

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H⁺

This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds.

References

↑ Inoue, J., Shaw, J.P., Rekik, M. and Harayama, S. (1995). "Overlapping substrate specificities of benzaldehyde dehydrogenase (the xylC gene product) and 2-hydroxymuconic semialdehyde dehydrogenase (the xylG gene product) encoded by TOL plasmid pWW0 of Pseudomonas putida". J. Bacteriol. 177 (5): 1196–1201. PMC 176723. PMID 7868591.
↑ Orii, C., Takenaka, S., Murakami, S. and Aoki, K. (2006). "Metabolism of 4-amino-3-hydroxybenzoic acid by Bordetella sp. strain 10d: A different modified meta-cleavage pathway for 2-aminophenols". Biosci. Biotechnol. Biochem. 70 (11): 2653–2661. doi:10.1271/bbb.60264. PMID 17090920.
↑ Kasai, D., Fujinami, T., Abe, T., Mase, K., Katayama, Y., Fukuda, M. and Masai, E. (2009). "Uncovering the protocatechuate 2,3-cleavage pathway genes". J. Bacteriol. 191 (21): 6758–6768. doi:10.1128/JB.00840-09. PMC 2795304. PMID 19717587.

External links

2-hydroxymuconate-6-semialdehyde dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)

Aldehyde/oxo oxidoreductases (EC 1.2)

1.2.1: NAD or NADP	Aldehyde dehydrogenase Acetaldehyde dehydrogenase Long-chain-aldehyde dehydrogenase

1.2.2: cytochrome	Formate dehydrogenase (cytochrome)

1.2.3: oxygen	Aldehyde oxidase

1.2.4: disulfide	Oxoglutarate dehydrogenase complex Pyruvate dehydrogenase Branched-chain alpha-keto acid dehydrogenase complex BCKDHA BCKDHB DBT DLD

1.2.7: iron-sulfur protein	Pyruvate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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