2-hydroxymuconate tautomerase

2-hydroxymuconate tautomerase
Identifiers
EC number	5.3.2.6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-hydroxymuconate tautomerase (EC 5.3.2.6, 4-oxalocrotonate tautomerase, 4-oxalocrotonate isomerase, cnbG (gene), praC (gene), xylH (gene)) is an enzyme with systematic name (2Z,4E)-2-hydroxyhexa-2,4-dienedioate keto-enol isomerase.^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate $\rightleftharpoons$ (3E)-2-oxohex-3-enedioate

Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols.

References

1. Whitman, C.P., Aird, B.A., Gillespie, W.R. and Stolowich, N.J. (1991). "Chemical and enzymatic ketonization of 2-hydroxymuconate, a conjugated enol". J. Am. Chem. Soc. 113: 3154–3162. doi:10.1021/ja00008a052.
2. Whitman, C.P., Hajipour, G., Watson, R.J., Johnson, W.H., Jr., Bembenek, M.E. and Stolowich, N.J. (1992). "Stereospecific ketonization of 2-hydroxymuconate by 4-oxalocrotonate tautomerase and 5-(carboxymethyl)-2-hydroxymuconate isomerase". J. Am. Chem. Soc. 114: 10104–10110. doi:10.1021/ja00052a002.
3. Subramanya, H.S., Roper, D.I., Dauter, Z., Dodson, E.J., Davies, G.J., Wilson, K.S. and Wigley, D.B. (1996). "Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases". Biochemistry 35 (3): 792–802. doi:10.1021/bi951732k. PMID 8547259.
4. Stivers, J.T., Abeygunawardana, C., Mildvan, A.S., Hajipour, G., Whitman, C.P. and Chen, L.H. (1996). "Catalytic role of the amino-terminal proline in 4-oxalocrotonate tautomerase: affinity labeling and heteronuclear NMR studies". Biochemistry 35 (3): 803–813. doi:10.1021/bi951077g. PMID 8547260.
5. Wang, S.C., Johnson, W.H., Jr., Czerwinski, R.M., Stamps, S.L. and Whitman, C.P. (2007). "Kinetic and stereochemical analysis of YwhB, a 4-oxalocrotonate tautomerase homologue in Bacillus subtilis: mechanistic implications for the YwhB- and 4-oxalocrotonate tautomerase-catalyzed reactions". Biochemistry 46 (42): 11919–11929. doi:10.1021/bi701231a. PMID 17902707.
6. Kasai, D., Fujinami, T., Abe, T., Mase, K., Katayama, Y., Fukuda, M. and Masai, E. (2009). "Uncovering the protocatechuate 2,3-cleavage pathway genes". J. Bacteriol. 191: 6758–6768. doi:10.1128/JB.00840-09. PMC 2795304. PMID 19717587.

External links

• 2-hydroxymuconate tautomerase at the US National Library of Medicine Medical Subject Headings (MeSH)