23S rRNA pseudouridine1911/1915/1917 synthase

23S rRNA pseudouridine^1911/1915/1917 synthase
Identifiers
EC number	5.4.99.23
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

23S rRNA pseudouridine^{1911/1915/1917} synthase (EC 5.4.99.23, RluD, pseudouridine synthase RluD) is an enzyme with systematic name 23S rRNA-uridine^{1911/1915/1917} uracil mutase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

23S rRNA uridine¹⁹¹¹/uridine¹⁹¹⁵/uridine¹⁹¹⁷ $\rightleftharpoons$ 23S rRNA pseudouridine¹⁹¹¹/pseudouridine¹⁹¹⁵/pseudouridine¹⁹¹⁷

These nucleotides are located in the functionally important helix-loop 69 of 23S rRNA.

References

1. Leppik, M., Peil, L., Kipper, K., Liiv, A. and Remme, J. (2007). "Substrate specificity of the pseudouridine synthase RluD in Escherichia coli". FEBS J. 274: 5759–5766. doi:10.1111/j.1742-4658.2007.06101.x. PMID 17937767.
2. Ejby, M., Sorensen, M.A. and Pedersen, S. (2007). "Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination". Proc. Natl. Acad. Sci. USA 104: 19410–19415. doi:10.1073/pnas.0706558104. PMID 18032607.
3. Sivaraman, J., Iannuzzi, P., Cygler, M. and Matte, A. (2004). "Crystal structure of the RluD pseudouridine synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli". J. Mol. Biol. 335: 87–101. doi:10.1016/j.jmb.2003.10.003. PMID 14659742.
4. Wrzesinski, J., Bakin, A., Ofengand, J. and Lane, B.G. (2000). "Isolation and properties of Escherichia coli 23S-RNA pseudouridine 1911, 1915, 1917 synthase (RluD)". IUBMB Life 50: 33–37. doi:10.1080/15216540050176566. PMID 11087118.

External links

• 23S rRNA pseudouridine1911/1915/1917 synthase at the US National Library of Medicine Medical Subject Headings (MeSH)