23S rRNA pseudouridine2604 synthase

23S rRNA pseudouridine^2604 synthase
Identifiers
EC number	5.4.99.21
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

23S rRNA pseudouridine2604 synthase (EC 5.4.99.21, RluF, YjbC) is an enzyme with systematic name 23S rRNA-uridine2604 uracil mutase.^[1][2][3] This enzyme catalyses the following chemical reaction

23S rRNA uridine²⁶⁰⁴ $\rightleftharpoons$ 23S rRNA pseudouridine²⁶⁰⁴

The enzyme can, to a small extent, also react with uridine²⁶⁰⁵.

References

1. Del Campo, M., Kaya, Y. and Ofengand, J. (2001). "Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli". RNA 7: 1603–1615. PMID 11720289.
2. Alian, A., DeGiovanni, A., Griner, S.L., Finer-Moore, J.S. and Stroud, R.M. (2009). "Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U²⁶⁰⁴ of the ribosome". J. Mol. Biol. 388: 785–800. doi:10.1016/j.jmb.2009.03.029. PMID 19298824.
3. Sunita, S., Zhenxing, H., Swaathi, J., Cygler, M., Matte, A. and Sivaraman, J. (2006). "Domain organization and crystal structure of the catalytic domain of E. coli RluF, a pseudouridine synthase that acts on 23S rRNA". J. Mol. Biol. 359: 998–1009. doi:10.1016/j.jmb.2006.04.019. PMID 16712869.

External links

• 23S rRNA pseudouridine2604 synthase at the US National Library of Medicine Medical Subject Headings (MeSH)