23S rRNA pseudouridine746 synthase

23S rRNA pseudouridine^746 synthase
Identifiers
EC number	5.4.99.29
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

23S rRNA pseudouridine⁷⁴⁶ synthase (EC 5.4.99.29, RluA, 23S RNA PSI⁷⁴⁶ synthase, 23S rRNA pseudouridine synthase, pseudouridine synthase RluA) is an enzyme with systematic name 23S rRNA-uridine⁷⁴⁶ uracil mutase.^[1][2][3] This enzyme catalyses the following chemical reaction

23S rRNA uridine⁷⁴⁶ $\rightleftharpoons$ 23S rRNA pseudouridine⁷⁴⁶

RluA is the only protein responsible for the in vivo formation of 23S RNA pseudouridine⁷⁴⁶.

References

1. Hoang, C., Chen, J., Vizthum, C.A., Kandel, J.M., Hamilton, C.S., Mueller, E.G. and Ferre-D'Amare, A.R. (2006). "Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure". Mol. Cell 24: 535–545. doi:10.1016/j.molcel.2006.09.017. PMID 17188032.
2. Raychaudhuri, S., Niu, L., Conrad, J., Lane, B.G. and Ofengand, J. (1999). "Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA". J. Biol. Chem. 274: 18880–18886. doi:10.1074/jbc.274.27.18880. PMID 10383384.
3. Wrzesinski, J., Nurse, K., Bakin, A., Lane, B.G. and Ofengand, J. (1995). "A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for Ψ⁷⁴⁶ in 23S RNA is also specific for Ψ³² in tRNA^Phe". RNA 1: 437–448. PMID 7493321.

External links

• 23S rRNA pseudouridine746 synthase at the US National Library of Medicine Medical Subject Headings (MeSH)