23S rRNA pseudouridine955/2504/2580 synthase

23S rRNA pseudouridine^955/2504/2580 synthase
Identifiers
EC number	5.4.99.24
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

23S rRNA pseudouridine^{955/2504/2580} synthase (EC 5.4.99.24, RluC, pseudouridine synthase RluC) is an enzyme with systematic name 23S rRNA-uridine^{955/2504/2580} uracil mutase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

23S rRNA uridine⁹⁵⁵/uridine²⁵⁰⁴/uridine²⁵⁸⁰ $\rightleftharpoons$ 23S rRNA pseudouridine⁹⁵⁵/pseudouridine²⁵⁰⁴/pseudouridine²⁵⁸⁰

The enzyme converts uridines at position 955, 2504 and 2580 of 23S rRNA to pseudouridines.

References

1. Jiang, M., Sullivan, S.M., Walker, A.K., Strahler, J.R., Andrews, P.C. and Maddock, J.R. (2007). "Identification of novel Escherichia coli ribosome-associated proteins using isobaric tags and multidimensional protein identification techniques". J. Bacteriol. 189: 3434–3444. doi:10.1128/jb.00090-07. PMID 17337586.
2. Conrad, J., Sun, D., Englund, N. and Ofengand, J. (1998). "The rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA". J. Biol. Chem. 273: 18562–18566. doi:10.1074/jbc.273.29.18562. PMID 9660827.
3. Corollo, D., Blair-Johnson, M., Conrad, J., Fiedler, T., Sun, D., Wang, L., Ofengand, J. and Fenna, R. (1999). "Crystallization and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli". Acta Crystallogr. D Biol. Crystallogr. 55: 302–304. doi:10.1107/s090744499801021x. PMID 10089432.
4. Toh, S.M. and Mankin, A.S. (2008). "An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors". J. Mol. Biol. 380: 593–597. doi:10.1016/j.jmb.2008.05.027. PMID 18554609.

External links

• 23S rRNA pseudouridine955/2504/2580 synthase at the US National Library of Medicine Medical Subject Headings (MeSH)