3-Succinoylsemialdehyde-pyridine dehydrogenase

3-Succinoylsemialdehyde-pyridine dehydrogenase (EC 1.2.1.83) is an enzyme with systematic name 4-oxo-4-(pyridin-3-yl)butanal:NADP⁺ oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

4-oxo-4-(pyridin-3-yl)butanal + NADP⁺ + H₂O

\rightleftharpoons

4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H⁺

The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6.

References

↑ Qiu, J., Ma, Y., Wen, Y., Chen, L., Wu, L. and Liu, W. (2012). "Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine". Appl. Environ. Microbiol. 78 (7): 2154–2160. doi:10.1128/AEM.07025-11. PMC 3302611. PMID 22267672.

External links

3-succinoylsemialdehyde-pyridine dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)

Aldehyde/oxo oxidoreductases (EC 1.2)

1.2.1: NAD or NADP	Aldehyde dehydrogenase Acetaldehyde dehydrogenase Long-chain-aldehyde dehydrogenase

1.2.2: cytochrome	Formate dehydrogenase (cytochrome)

1.2.3: oxygen	Aldehyde oxidase

1.2.4: disulfide	Oxoglutarate dehydrogenase complex Pyruvate dehydrogenase Branched-chain alpha-keto acid dehydrogenase complex BCKDHA BCKDHB DBT DLD

1.2.7: iron-sulfur protein	Pyruvate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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