4'-demethylrebeccamycin synthase

4'-demethylrebeccamycin synthase
Identifiers
EC number	4.3.3.5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

4'-demethylrebeccamycin synthase (EC 4.3.3.5, arcyriaflavin A N-glycosyltransferase, RebG) is an enzyme with systematic name 4'-demethylrebeccamycin D-glucose-lyase.^[1][2] This enzyme catalyses the following chemical reaction

4'-O-demethylrebeccamycin + H2O $\rightleftharpoons$ dichloro-arcyriaflavin A + beta-D-glucose

This enzyme catalyses a step in the biosynthesis of rebeccamycin.

References

1. Ohuchi, T., Ikeda-Araki, A., Watanabe-Sakamoto, A., Kojiri, K., Nagashima, M., Okanishi, M. and Suda, H. (2000). "Cloning and expression of a gene encoding N-glycosyltransferase (ngt) from Saccharothrix aerocolonigenes ATCC39243". J. Antibiot. (Tokyo) 53 (4): 393–403. doi:10.7164/antibiotics.53.393. PMID 10866221.
2. Zhang, C., Albermann, C., Fu, X., Peters, N.R., Chisholm, J.D., Zhang, G., Gilbert, E.J., Wang, P.G., Van Vranken, D.L. and Thorson, J.S. (2006). "RebG- and RebM-catalyzed indolocarbazole diversification". Chembiochem 7: 795–804. doi:10.1002/cbic.200500504. PMID 16575939.

External links

• 4'-demethylrebeccamycin synthase at the US National Library of Medicine Medical Subject Headings (MeSH)