Pethidine intermediate A
 | |
| Systematic (IUPAC) name | |
|---|---|
|
1-methyl-4-phenylpiperidine-4-carbonitrile | |
| Clinical data | |
| Routes of administration | N/A |
| Legal status |
|
| Identifiers | |
| CAS Number | 3627-62-1 |
| ATC code | None |
| PubChem | CID 62513 |
| Chemical data | |
| Formula | C13H16N2 |
| Molar mass | 200.28 g/mol |
| (verify) | |
Pethidine intermediate A is a 4-phenylpiperidine derivative that is a precursor to the opioid analgesic drug pethidine (meperidine). It is not known to have any analgesic activity in its own right, however other derivatives of pethidine with a 4-cyano group in place of the carboxylate ethyl ester have been found to be active,[1] so pethidine intermediate A might also show opioid effects. It is scheduled by UN Single Convention on Narcotic Drugs. It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9232. The 2014 annual manufacturing quota was 6 grammes (as an end product, presumably for research use). [2]
See also
- Moramide intermediate
- Methadone intermediate
- Pethidine intermediate B (norpethidine)
- Pethidine intermediate C (pethidinic acid)
References
- ↑ Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML. Synthesis and Biological Evaluation of Meperidine Analogues at Monoamine Transporters. Journal of Medicinal Chemistry. 2005; 48:1336-1343.
- ↑ http://www.deadiversion.usdoj.gov/quotas/conv_factor/index.html
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