4-Dimethylaminophenol
Not to be confused with 4-Dimethylaminopyridine.
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| Identifiers | |
|---|---|
619-60-3  | |
| ChemSpider | 20816  |
| Jmol interactive 3D | Image |
| PubChem | 22174 |
| UNII | X387L5559O |
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| |
| Properties | |
| C8H11NO | |
| Molar mass | 137.179 g/mol |
| Boiling point | 165 °C (329 °F; 438 K) (0.040 bar) |
| Pharmacology | |
| ATC code | V03 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| verify (what is ?) | |
| Infobox references | |
4-Dimethylaminophenol (abbreviated in medical practice as DMAP) is an aromatic compound containing both phenol and amine functional groups. It has the molecular formula C8H11NO.
Uses
4-Dimethylaminophenol has been used as an antidote for cyanide poisoning.[1] It has also been shown to be effective in treating hydrogen sulfide toxicity.[2]
It works by generating methemoglobin. [3]
This is suitable as an emergency treatment only; treatment must be followed up with sodium thiosulfate or cobalamin.
In an animal model, it has shown effectiveness when given intramuscularly.[4] Though, intramuscular injection should be avoid due to the probability of muscular necrosis after injection. Intravenous injection is recommended in a dose of 250mg.[5]
See also
References
- ↑ Kampe S, Iffland R, Korenkov M, Diefenbach C (December 2000). "Survival from a lethal blood concentration of cyanide with associated alcohol intoxication". Anaesthesia 55 (12): 1189–91. doi:10.1046/j.1365-2044.2000.01628.x. PMID 11121929.
- ↑ Lindenmann J, Matzi V, Neuboeck N, Ratzenhofer-Komenda B, Maier A, Smolle-Juettner FM (December 2010). "Severe hydrogen sulphide poisoning treated with 4-dimethylaminophenol and hyperbaric oxygen". Diving and Hyperbaric Medicine : the Journal of the South Pacific Underwater Medicine Society 40 (4): 213–7. PMID 23111938. Retrieved 2013-06-07.
- ↑ Vick JA, Von Bredow JD (1996). "Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival". J Appl Toxicol 16 (6): 509–16. doi:10.1002/(SICI)1099-1263(199611)16:6<509::AID-JAT382>3.0.CO;2-V. PMID 8956097.
- ↑ Vick JA, Froehlich H (July 1991). "Treatment of cyanide poisoning". Mil Med 156 (7): 330–9. PMID 1922842.
- ↑ Federation Of American Scientists (1 February 1996). "NATO HANDBOOK ON THE MEDICAL ASPECTS OF NBC DEFENSIVE OPERATIONS" (PDF): 334.
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