4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase

4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase
Identifiers
EC number	1.2.1.45
CAS number	67272-39-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.45) is an enzyme that catalyzes the chemical reaction

4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP⁺ + H₂O $\rightleftharpoons$ 4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + 2 H⁺

The 3 substrates of this enzyme are 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde, NADP⁺, and H₂O, whereas its 3 products are 4-carboxy-2-hydroxy-cis,cis-muconate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ 6-oxidoreductase. Other names in common use include 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+, oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde, and dehydrogenase. This enzyme participates in tyrosine metabolism and benzoate degradation via hydroxylation.

References

• Maruyama K, Ariga N, Tsuda M, Deguchi K (April 1978). "Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase". J. Biochem. (Tokyo) 83 (4): 1125–34. PMID 26671.