4-chlorobenzoate dehalogenase
| 4-chlorobenzoate dehalogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.8.1.6 | ||||||||
| CAS number | 94047-11-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a 4-chlorobenzoate dehalogenase (EC 3.8.1.6) is an enzyme that catalyzes the chemical reaction
- 4-chlorobenzoate + H2O
4-hydroxybenzoate + chloride
Thus, the two substrates of this enzyme are 4-chlorobenzoate and H2O, whereas its two products are 4-hydroxybenzoate and chloride.
This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 4-chlorobenzoate chlorohydrolase. This enzyme is also called halobenzoate dehalogenase.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1BVQ, 1JXZ, and 1NZY.
References
- Muller R, Thiele J, Klages U, Lingens F (1984). "Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3". Biochem. Biophys. Res. Commun. 124 (1): 178–82. doi:10.1016/0006-291X(84)90933-1. PMID 6497878.
- Heppel LA and Porterfield VT (1948). "Enzymatic dehalogenation of certain brominated and chlorinated compounds". J. Biol. Chem. 176 (2): 763–769. PMID 18889931.
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