5-Fluoroorotic acid

5-Fluoroorotic acid
Names
IUPAC name
5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid
Identifiers
703-95-7
ChemSpider 62912
Jmol interactive 3D Image
PubChem 69711
Properties
C5H3FN2O4
Molar mass 174.09 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

5-Fluoroorotic acid (5FOA) is a fluorinated derivative of the pyrimidine precursor orotic acid. It is used in yeast genetics to select for the absence of the URA3 gene, which encodes the enzyme for the decarboxylation of 5-fluoroorotic acid to 5-fluorouracil, a toxic metabolite.[1]

References

  1. "5-Fluoroorotic acid as a selective agent in yeast molecular genetics." 154. 1987: 164–75. PMID 3323810.


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