6-Deoxy-5-ketofructose 1-phosphate synthase

6-deoxy-5-ketofructose 1-phosphate synthase
Identifiers
EC number	2.2.1.11
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

6-deoxy-5-ketofructose 1-phosphate synthase (EC 2.2.1.11, DKFP synthase, MJ1585 (gene)) is an enzyme with systematic name 2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase.^[1][2] This enzyme catalyses the following chemical reaction

(1) methylglyoxal + D-fructose 1,6-bisphosphate $\rightleftharpoons$ D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate

(2) methylglyoxal + D-fructose 1-phosphate $\rightleftharpoons$ D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate

This enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate.

References

1. White, R.H. and Xu, H. (2006). "Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii". Biochemistry 45: 12366–12379. doi:10.1021/bi061018a. PMID 17014089.
2. Samland, A.K., Wang, M. and Sprenger, G.A. (2008). "MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity". FEMS Microbiol. Lett. 281: 36–41. doi:10.1111/j.1574-6968.2008.01079.x. PMID 18318840.

External links

• 6-deoxy-5-ketofructose 1-phosphate synthase at the US National Library of Medicine Medical Subject Headings (MeSH)