7-carboxy-7-deazaguanine synthase

7-carboxy-7-deazaguanine synthase (EC 4.3.99.3, 7-carboxy-7-carbaguanine synthase, queE (gene)) is an enzyme with systematic name 6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase.^[1] This enzyme catalyses the following chemical reaction

6-carboxy-5,6,7,8-tetrahydropterin

\rightleftharpoons

7-carboxy-7-carbaguanine + NH₃

The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical enzymes.

References

↑ McCarty, R.M., Somogyi, A., Lin, G., Jacobsen, N.E. and Bandarian, V. (2009). "The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of preQ₀ from guanosine 5′-triphosphate in four steps". Biochemistry 48: 3847–3852. doi:10.1021/bi900400e. PMID 19354300.

External links

7-carboxy-7-deazaguanine synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-nitrogen lyases (EC 4.3)

4.3.1: ammonia-lyases	Histidine ammonia-lyase Formiminotransferase cyclodeaminase Serine dehydratase

4.3.2: amidine-lyases	Argininosuccinate lyase Adenylosuccinate lyase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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