77-LH-28-1

77-LH-28-1

Names
IUPAC name 1-[3-(4-Butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)-quinolinone
Identifiers
CAS Number	560085-11-2
ChemSpider	8412246
IUPHAR/BPS	3271
Jmol interactive 3D	Image
PubChem	10236758
InChI InChI=1S/C21H32N2O/c1-2-3-7-18-12-16-22(17-13-18)14-6-15-23-20-9-5-4-8-19(20)10-11-21(23)24/h4-5,8-9,18H,2-3,6-7,10-17H2,1H3 Key: PHMGZAICAOYEAF-UHFFFAOYSA-N
SMILES O=C2N(c1ccccc1CC2)CCCN3CCC(CC3)CCCC
Properties
Chemical formula	C21H32N2O
Molar mass	328.50 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

77-LH-28-1 is a selective agonist of muscarinic acetylcholine receptor subtype 1 (M₁) discovered in 2008. It is an allosteric agonist, exhibiting over 100-fold specificity for M₁ over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the blood brain barrier and is therefore a useful pharmocologic tool with cognition enhancing effects.^[1]

References

1. C J Langmead, N E Austin, C L Branch, J T Brown, K A Buchanan, C H Davies, I T Forbes, V A H Fry, J J Hagan, H J Herdon, G A Jones, R Jeggo, J N C Kew, A Mazzali, R Melarange, N Patel, J Pardoe, A D Randall, C Roberts, A Roopun, K R Starr, A Teriakidis, M D Wood, M Whittington, Z Wu, and J Watson (2008). "Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1". Br J Pharmacol 154 (5): 1104–1115. doi:10.1038/bjp.2008.152. PMC 2451039. PMID 18454168.