8-Hydroxy-5-deazaflavin:NADPH oxidoreductase

8-Hydroxy-5-deazaflavin:NADPH oxidoreductase (EC 1.5.1.40, 8-OH-5dFl:NADPH oxidoreductase) is an enzyme with systematic name reduced coenzyme F420:NADP⁺ oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

reduced coenzyme F420 + NADP⁺

\rightleftharpoons

coenzyme F420 + NADPH + H⁺

The enzyme requires the 5-deazaflavin structure, as well as an 8-hydroxy group in the substrate.

References

↑ Eker, A.P., Hessels, J.K. and Meerwaldt, R. (1989). "Characterization of an 8-hydroxy-5-deazaflavin:NADPH oxidoreductase from Streptomyces griseus". Biochim. Biophys. Acta 990: 80–86. doi:10.1016/s0304-4165(89)80015-7. PMID 2492438.

External links

8-hydroxy-5-deazaflavin:NADPH oxidoreductase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: CH-NH (EC 1.5)

1.5.1: NAD or NADP acceptor	Dihydrofolate reductase Saccharopine dehydrogenase Methylenetetrahydrofolate reductase

1.5.3: oxygen acceptor	Dihydrobenzophenanthridine oxidase Sarcosine oxidase Proline oxidase

1.5.5: quinone acceptor	Electron-transferring-flavoprotein dehydrogenase

1.5.99	Sarcosine dehydrogenase Cytokinin dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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