9,12-octadecadienoate 8-hydroperoxide 8S-isomerase

9,12-octadecadienoate 8-hydroperoxide 8S-isomerase
Identifiers
EC number	5.4.4.6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

9,12-octadecadienoate 8-hydroperoxide 8S-isomerase (EC 5.4.4.6, 8-hydroperoxide isomerase, (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-7,8-dihydroxy-9,12-octadecadienoate-forming)) is an enzyme with systematic name (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase ((7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate-forming).^[1][2][3] This enzyme catalyses the following chemical reaction

(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate $\rightleftharpoons$ (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate

This enzyme contains heme.

References

1. Hamberg, M., Zhang, L.-Y., Brodowsky, I.D. and Oliw, E.H. (1994). "Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions". Arch. Biochem. Biophys. 309: 77–80. doi:10.1006/abbi.1994.1087. PMID 8117115.
2. Su, C., Sahlin, M. and Oliw, E.H. (1998). "A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities". J. Biol. Chem. 273: 20744–20751. doi:10.1074/jbc.273.33.20744. PMID 9694817.
3. Su, C. and Oliw, E.H. (1996). "Purification and characterization of linoleate 8-dioxygenase from the fungus Gaeumannomyces graminis as a novel hemoprotein". J. Biol. Chem. 271: 14112–14118. doi:10.1074/jbc.271.24.14112. PMID 8662736.

External links

• 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase at the US National Library of Medicine Medical Subject Headings (MeSH)