AADAC

Arylacetamide deacetylase
Identifiers
Symbols AADAC ; CES5A1; DAC
External IDs OMIM: 600338 MGI: 1915008 HomoloGene: 37436 GeneCards: AADAC Gene
EC number 3.1.1.3
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 13 67758
Ensembl ENSG00000114771 ENSMUSG00000027761
UniProt P22760 Q99PG0
RefSeq (mRNA) NM_001086 NM_023383
RefSeq (protein) NP_001077 NP_075872
Location (UCSC) Chr 3:
151.81 – 151.83 Mb
Chr 3:
60.03 – 60.04 Mb
PubMed search

Arylacetamide deacetylase is an enzyme that in humans is encoded by the AADAC gene.[1][2]

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens[2]

References

  1. Probst MR, Beer M, Beer D, Jeno P, Meyer UA, Gasser R (Sep 1994). "Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase.". J Biol Chem 269 (34): 21650–6. PMID 8063807.
  2. 1 2 "Entrez Gene: AADAC arylacetamide deacetylase (esterase)".

Further reading

External links


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