ABCC12

ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Identifiers
Symbols	ABCC12 ; MRP9
External IDs	OMIM: 607041 MGI: 2441679 HomoloGene: 57211 GeneCards: ABCC12 Gene
Gene ontology Molecular function • ATP binding • ATPase activity, coupled to transmembrane movement of substances Cellular component • mitochondrion • integral component of membrane Biological process • metabolic process • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	94160	244562
Ensembl	ENSG00000140798	ENSMUSG00000036872
UniProt	Q96J65	Q80WJ6
RefSeq (mRNA)	NM_033226	NM_172912
RefSeq (protein)	NP_150229	NP_766500
Location (UCSC)	Chr 16: 48.08 – 48.16 Mb	Chr 8: 86.48 – 86.58 Mb
PubMed search

Multidrug resistance-associated protein 9 is a protein that in humans is encoded by the ABCC12 gene.^[1][2][3]

Function

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.^[3]

References

1. Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397.
2. Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, Schuetz JD, Swoboda KJ, Ptacek LJ, Rosier M, Dean M, Allikmets R (Aug 2001). "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12". Gene 273 (1): 89–96. doi:10.1016/S0378-1119(01)00572-8. PMID 11483364.
3. "Entrez Gene: ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12".

Further reading

• Haimeur A, Conseil G, Deeley RG, Cole SP (2004). "The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation.". Curr. Drug Metab. 5 (1): 21–53. doi:10.2174/1389200043489199. PMID 14965249.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bera TK, Iavarone C, Kumar V; et al. (2002). "MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6997–7002. doi:10.1073/pnas.102187299. PMC 124517. PMID 12011458.
• Yabuuchi H, Shimizu H, Takayanagi S, Ishikawa T (2001). "Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12". Biochem. Biophys. Res. Commun. 288 (4): 933–9. doi:10.1006/bbrc.2001.5865. PMID 11688999.