ABCE1

ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily.[1]

ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L,[2] and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumor cell proliferation and antiapoptosis.[3]

References

  1. ↑ "ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 [ Homo sapiens ]". Retrieved 14 March 2013.
  2. ↑ "P61221 (ABCE1_HUMAN)".
  3. ↑ Tian, Y; Han, X; Tian, DL (2012). "The biological regulation of ABCE1". IUBMB Life 64 (10): 795–800. doi:10.1002/iub.1071. PMID 23008114.

External links

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