ABI2

Abl-interactor 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2ED0​, 3P8C​, 4N78​
Identifiers
Symbols	ABI2 ; ABI-2; ABI2B; AIP-1; AblBP3; SSH3BP2; argBP1; argBPIA; argBPIB
External IDs	OMIM: 606442 MGI: 106913 HomoloGene: 4209 GeneCards: ABI2 Gene
Gene ontology Molecular function • DNA binding • protein binding • cytoskeletal adaptor activity • SH3 domain binding • kinase binding • ubiquitin protein ligase binding • protein complex binding • Rac GTPase binding • proline-rich region binding Cellular component • cytoplasm • cytosol • cytoskeleton • lamellipodium • filopodium • SCAR complex Biological process • movement of cell or subcellular component • cytoskeleton organization • actin polymerization or depolymerization • viral process • cell migration • Rac protein signal transduction • peptidyl-tyrosine phosphorylation • positive regulation of Arp2/3 complex-mediated actin nucleation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10152	329165
Ensembl	ENSG00000138443	ENSMUSG00000026782
UniProt	Q9NYB9	P62484
RefSeq (mRNA)	NM_001282925	NM_001198570
RefSeq (protein)	NP_001269854	NP_001185499
Location (UCSC)	Chr 2: 203.33 – 203.45 Mb	Chr 1: 60.41 – 60.48 Mb
PubMed search

Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ABI2 gene.^[1][2][3]

Interactions

ABI2 has been shown to interact with ABL1,^[1][4]ADAM19,^[5] and TRIM32.^[6]

References

1. Dai Z, Pendergast AM (Dec 1995). "Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity". Genes Dev 9 (21): 2569–82. doi:10.1101/gad.9.21.2569. PMID 7590236.
2. Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (Sep 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
3. "Entrez Gene: ABI2 abl interactor 2".
4. Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
5. Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (September 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424.
6. Kano S, Miyajima N, Fukuda S, Hatakeyama S (July 2008). "Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2". Cancer Res. 68 (14): 5572–80. doi:10.1158/0008-5472.CAN-07-6231. PMID 18632609.

Further reading

• Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review).". Int. J. Mol. Med. 9 (6): 591–5. doi:10.3892/ijmm.9.6.591. PMID 12011975.
• Wang B, Mysliwiec T, Krainc D; et al. (1996). "Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene.". Oncogene 12 (9): 1921–9. PMID 8649853.
• Juang JL, Hoffmann FM (1999). "Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity.". Oncogene 18 (37): 5138–47. doi:10.1038/sj.onc.1202911. PMID 10498863.
• Chen B, Borinstein SC, Gillis J; et al. (2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes.". J. Biol. Chem. 275 (25): 19275–81. doi:10.1074/jbc.M908994199. PMID 10858458.
• Machado RD, Pauciulo MW, Fretwell N; et al. (2001). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium.". Genomics 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
• Courtney KD, Grove M, Vandongen H; et al. (2000). "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.". Mol. Cell. Neurosci. 16 (3): 244–57. doi:10.1006/mcne.2000.0865. PMID 10995551.
• Stradal T, Courtney KD, Rottner K; et al. (2001). "The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.". Curr. Biol. 11 (11): 891–5. doi:10.1016/S0960-9822(01)00239-1. PMID 11516653.
• Huang L, Feng L, Yang L; et al. (2003). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424.
• Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cao C, Leng Y, Li C, Kufe D (2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Eastman SW, Martin-Serrano J, Chung W; et al. (2005). "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding". J. Biol. Chem. 280 (1): 628–36. doi:10.1074/jbc.M410384200. PMID 15509564.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Luo X, Levens E, Williams RS, Chegini N (2006). "The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta". Hum. Reprod. 21 (6): 1380–6. doi:10.1093/humrep/del011. PMID 16488906.
• Hirao N, Sato S, Gotoh T; et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation". FEBS Lett. 580 (27): 6464–70. doi:10.1016/j.febslet.2006.10.065. PMID 17101133.
• Li Y, Clough N, Sun X; et al. (2007). "BCR-ABL Induces Abnormal Cytoskeleton Remodeling, β1 Integrin Clustering, and Increased Cell Adhesion to Fibronectin Through ABL Interactor 1 Pathway". J. Cell. Sci. 120 (Pt 8): 1436–46. doi:10.1242/jcs.03430. PMC 1950936. PMID 17389688.

External links

• ABI2 human gene location in the UCSC Genome Browser.
• ABI2 human gene details in the UCSC Genome Browser.