ABI gene family member 3

ABI family, member 3
Identifiers
Symbols	ABI3 ; NESH; SSH3BP3
External IDs	OMIM: 606363 MGI: 1913860 HomoloGene: 9505 GeneCards: ABI3 Gene
Gene ontology Molecular function • protein binding Cellular component • intracellular • cytoplasm • membrane • lamellipodium Biological process • movement of cell or subcellular component • peptidyl-tyrosine phosphorylation • regulation of cell migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51225	66610
Ensembl	ENSG00000108798	ENSMUSG00000018381
UniProt	Q9P2A4	Q8BYZ1
RefSeq (mRNA)	NM_001135186	NM_001163464
RefSeq (protein)	NP_001128658	NP_001156936
Location (UCSC)	Chr 17: 49.21 – 49.22 Mb	Chr 11: 95.83 – 95.84 Mb
PubMed search

ABI gene family member 3 (ABI3) also known as new molecule including SH3 (Nesh) is a protein that in humans is encoded by the ABI3 gene.^[1][2][3]

Function

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinases.^[3]

References

1. Miyazaki K, Matsuda S, Ichigotani Y, Takenouchi Y, Hayashi K, Fukuda Y, Nimura Y, Hamaguchi M (Nov 2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein". Biochim Biophys Acta 1493 (1-2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530.
2. Ichigotani Y, Yokozaki S, Fukuda Y, Hamaguchi M, Matsuda S (Apr 2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res 62 (8): 2215–9. PMID 11956071.
3. "Entrez Gene: ABI3 ABI gene family, member 3".

Further reading

• Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review).". Int. J. Mol. Med. 9 (6): 591–5. doi:10.3892/ijmm.9.6.591. PMID 12011975.
• Miyazaki K, Matsuda S, Ichigotani Y; et al. (2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein.". Biochim. Biophys. Acta 1493 (1-2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Matsuda S, Iriyama C, Yokozaki S; et al. (2001). "Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3.". J. Hum. Genet. 46 (8): 483–6. doi:10.1007/s100380170049. PMID 11501947.
• Ichigotani Y, Yokozaki S, Fukuda Y; et al. (2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells.". Cancer Res. 62 (8): 2215–9. PMID 11956071.
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Hirao N, Sato S, Gotoh T; et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.". FEBS Lett. 580 (27): 6464–70. doi:10.1016/j.febslet.2006.10.065. PMID 17101133.