ABRA (gene)

Actin binding Rho activating protein
Identifiers
Symbols	ABRA ; STARS
External IDs	OMIM: 609747 MGI: 2444891 HomoloGene: 34713 GeneCards: ABRA Gene
Gene ontology Molecular function • transcription coactivator activity • actin binding Cellular component • plasma membrane • actin cytoskeleton • sarcomere Biological process • protein import into nucleus, translocation • transcription, DNA-templated • positive regulation of Rho protein signal transduction • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	137735	223513
Ensembl	ENSG00000174429	ENSMUSG00000042895
UniProt	Q8N0Z2	Q8BUZ1
RefSeq (mRNA)	NM_139166	NM_175456
RefSeq (protein)	NP_631905	NP_780665
Location (UCSC)	Chr 8: 106.76 – 106.77 Mb	Chr 15: 41.87 – 41.87 Mb
PubMed search

Actin-binding Rho-activating protein is a protein that in humans is encoded by the ABRA gene.^[1] The mouse and rat homologues are known as STARS (striated muscle activator of Rho signalling) and MS1 (myocyte stress 1) respectively.^[2]

MS1/STARS is regulated by MyoD during myogenic differentiation of the C2C12 cell line.

References

1. Arai A, Spencer JA, Olson EN (Jul 2002). "STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription". J Biol Chem 277 (27): 24453–9. doi:10.1074/jbc.M202216200. PMID 11983702.
2. "Entrez Gene: ABRA actin-binding Rho activating protein".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Kuwahara K, Barrientos T, Pipes GC; et al. (2005). "Muscle-specific signaling mechanism that links actin dynamics to serum response factor.". Mol. Cell. Biol. 25 (8): 3173–81. doi:10.1128/MCB.25.8.3173-3181.2005. PMC 1069631. PMID 15798203.
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Kuwahara K, Teg Pipes GC, McAnally J; et al. (2007). "Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity.". J. Clin. Invest. 117 (5): 1324–34. doi:10.1172/JCI31240. PMC 1838928. PMID 17415416.