ACIN1

Apoptotic chromatin condensation inducer 1
Identifiers
Symbols	ACIN1 ; ACINUS; ACN; fSAP152
External IDs	OMIM: 604562 MGI: 1891824 HomoloGene: 22853 GeneCards: ACIN1 Gene
Gene ontology Molecular function • nucleotide binding • nucleic acid binding • protein binding • ATPase activity • enzyme binding • poly(A) RNA binding Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • cytosol • plasma membrane • nuclear speck • exon-exon junction complex • ASAP complex Biological process • positive regulation of defense response to virus by host • mRNA processing • apoptotic process • cellular component disassembly involved in execution phase of apoptosis • RNA splicing • programmed cell death • erythrocyte differentiation • apoptotic chromosome condensation • positive regulation of apoptotic process • positive regulation of monocyte differentiation • negative regulation of mRNA splicing, via spliceosome • activation of mitophagy in response to mitochondrial depolarization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22985	56215
Ensembl	ENSG00000100813	ENSMUSG00000022185
UniProt	Q9UKV3	Q9JIX8
RefSeq (mRNA)	NM_001164814	NM_001085472
RefSeq (protein)	NP_001158286	NP_001078941
Location (UCSC)	Chr 14: 23.06 – 23.1 Mb	Chr 14: 54.64 – 54.69 Mb
PubMed search

Apoptotic chromatin condensation inducer in the nucleus is a protein that in humans is encoded by the ACIN1 gene.^[1][2][3]

References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
2. Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (Sep 1999). "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation". Nature 401 (6749): 168–73. doi:10.1038/43678. PMID 10490026.
3. "Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1".

Further reading

• Zermati Y, Garrido C, Amsellem S; et al. (2001). "Caspase activation is required for terminal erythroid differentiation.". J. Exp. Med. 193 (2): 247–54. doi:10.1084/jem.193.2.247. PMC 2193347. PMID 11208865.
• Sordet O, Rébé C, Plenchette S; et al. (2003). "Specific involvement of caspases in the differentiation of monocytes into macrophages.". Blood 100 (13): 4446–53. doi:10.1182/blood-2002-06-1778. PMID 12393560.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shu H, Chen S, Bi Q; et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.". Mol. Cell Proteomics 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Hu Y, Yao J, Liu Z; et al. (2005). "Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation.". EMBO J. 24 (20): 3543–54. doi:10.1038/sj.emboj.7600823. PMC 1276706. PMID 16177823.
• Joselin AP, Schulze-Osthoff K, Schwerk C (2006). "Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis.". J. Biol. Chem. 281 (18): 12475–84. doi:10.1074/jbc.M509859200. PMID 16537548.
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Shu Y, Iijima T, Sun W; et al. (2007). "The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma.". Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 1 (2): 160–7. doi:10.1097/01243894-200602000-00010. PMID 17409846.