ACSL6

ACSL6
Identifiers
Aliases ACSL6, ACS2, FACL6, LACS 6, LACS2, LACS5
External IDs OMIM: 604443 MGI: 894291 HomoloGene: 100939 GeneCards: 23305
Orthologs
Species Human Mouse
Entrez

23305

216739

Ensembl

ENSG00000164398

ENSMUSG00000020333

UniProt

Q9UKU0
C9JPA5

Q91WC3

RefSeq (mRNA)
RefSeq (protein)

NP_001028770.1
XP_006532906.1
XP_006532907.1

Location (UCSC) Chr 5: 131.95 – 132.01 Mb Chr 11: 54.3 – 54.36 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene.[1][2][3] Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA.[2]

Structure

The ACSL6 gene is located on the 5th chromosome, with its specific location being 5q31.1. The gene contains 23 exons. [1] ACSL6 encodes a 77.7 kDa protein that is composed of 697 amino acids; 10 peptides have been observed through mass spectrometry data.[4][5]

References

  1. 1 2 "Entrez Gene: acyl-CoA synthetase long-chain family member 6".
  2. 1 2 Malhotra KT, Malhotra K, Lubin BH, Kuypers FA (November 1999). "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors". Biochem. J. 344 Pt 1 (Pt 1): 135–43. doi:10.1042/0264-6021:3440135. PMC 1220623. PMID 10548543.
  3. Yagasaki F, Jinnai I, Yoshida S, Yokoyama Y, Matsuda A, Kusumoto S, Kobayashi H, Terasaki H, Ohyashiki K, Asou N, Murohashi I, Bessho M, Hirashima K (November 1999). "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)". Genes Chromosomes Cancer 26 (3): 192–202. doi:10.1002/(SICI)1098-2264(199911)26:3<192::AID-GCC2>3.0.CO;2-E. PMID 10502316.
  4. ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
  5. "Long-chain-fatty-acid--CoA ligase 6". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).

Further reading


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