ACSM3

Acyl-CoA synthetase medium-chain family member 3
Identifiers
Symbols	ACSM3 ; SA; SAH
External IDs	OMIM: 145505 MGI: 99538 HomoloGene: 74559 GeneCards: ACSM3 Gene
EC number	6.2.1.2
Gene ontology Molecular function • molecular_function • ATP binding • fatty acid ligase activity • metal ion binding • butyrate-CoA ligase activity Cellular component • cellular_component • mitochondrial matrix Biological process • fatty acid biosynthetic process • regulation of blood pressure • cholesterol homeostasis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6296	20216
Ensembl	ENSG00000005187	ENSMUSG00000030935
UniProt	Q53FZ2	Q3UNX5
RefSeq (mRNA)	NM_005622	NM_016870
RefSeq (protein)	NP_005613	NP_058566
Location (UCSC)	Chr 16: 20.61 – 20.8 Mb	Chr 7: 119.76 – 119.79 Mb
PubMed search

Acyl-coenzyme A synthetase ACSM3, mitochondrial is an enzyme that in humans is encoded by the ACSM3 gene.^[1][2][3][4]

References

1. Nabika T, Bonnardeaux A, James M, Julier C, Jeunemaitre X, Corvol P, Lathrop M, Soubrier F (Jan 1995). "Evaluation of the SA locus in human hypertension". Hypertension 25 (1): 6–13. doi:10.1161/01.hyp.25.1.6. PMID 7843754.
2. Iwai N, Ohmichi N, Hanai K, Nakamura Y, Kinoshita M (Mar 1994). "Human SA gene locus as a candidate locus for essential hypertension". Hypertension 23 (3): 375–80. doi:10.1161/01.hyp.23.3.375. PMID 7907320.
3. Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT (Sep 2001). "Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product". The Journal of Biological Chemistry 276 (38): 35961–6. doi:10.1074/jbc.M106651200. PMID 11470804.
4. "Entrez Gene: ACSM3 acyl-CoA synthetase medium-chain family member 3".

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Samani NJ, Whitmore SA, Kaiser MA, Harris J, See CG, Callen DF, Lodwick D (Mar 1994). "Chromosomal assignment of the human SA gene to 16p13.11 and demonstration of its expression in the kidney". Biochemical and Biophysical Research Communications 199 (2): 862–8. doi:10.1006/bbrc.1994.1308. PMID 8135833.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Sep 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
• Iwai N, Katsuya T, Mannami T, Higaki J, Ogihara T, Kokame K, Ogata J, Baba S (Jan 2002). "Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension". Circulation 105 (1): 41–7. doi:10.1161/hc0102.101780. PMID 11772874.
• Narita I, Saito N, Goto S, Shirasaki A, Morioka Y, Jin S, Omori K, Sakatsume M, Arakawa M, Gejyo F (Nov 2002). "Role of genetic polymorphism in the SA gene on the blood pressure and prognosis of renal function in patients with immunoglobulin A nephropathy". Hypertension Research 25 (6): 831–6. doi:10.1291/hypres.25.831. PMID 12484505.
• Benjafield AV, Iwai N, Ishikawa K, Wang WY, Morris BJ (Aug 2003). "Overweight, but not hypertension, is associated with SAH polymorphisms in Caucasians with essential hypertension". Hypertension Research 26 (8): 591–5. doi:10.1291/hypres.26.591. PMID 14567496.
• Telgmann R, Brand E, Nicaud V, Hagedorn C, Beining K, Schönfelder J, Brink-Spalink V, Schmidt-Petersen K, Matanis T, Vischer P, Nofer JR, Hasenkamp S, Plouin PF, Drouet L, Cambien F, Paul M, Tiret L, Brand-Herrmann SM (Mar 2007). "SAH gene variants are associated with obesity-related hypertension in Caucasians: the PEGASE Study". Journal of Hypertension 25 (3): 557–64. doi:10.1097/HJH.0b013e3280144779. PMID 17278971.