ACTL6B

Actin-like 6B
Identifiers
Symbols	ACTL6B ; ACTL6; BAF53B
External IDs	OMIM: 612458 MGI: 1933548 HomoloGene: 81844 GeneCards: ACTL6B Gene
Gene ontology Molecular function • transcription coactivator activity • structural constituent of cytoskeleton Cellular component • nucleus • nucleolus • SWI/SNF complex • nBAF complex Biological process • chromatin organization • chromatin remodeling • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • spinal cord development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51412	83766
Ensembl	ENSG00000077080	ENSMUSG00000029712
UniProt	O94805	Q99MR0
RefSeq (mRNA)	NM_016188	NM_031404
RefSeq (protein)	NP_057272	NP_113581
Location (UCSC)	Chr 7: 100.64 – 100.66 Mb	Chr 5: 137.55 – 137.57 Mb
PubMed search

Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.^[1][2]

Function

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.^[2]

Interactions

ACTL6B has been shown to interact with CTBP1.^[3]

References

1. Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (December 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
2. "Entrez Gene: ACTL6B actin-like 6B".
3. Oma Y, Nishimori K, Harata M (February 2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP". Biochem. Biophys. Res. Commun. 301 (2): 521–528. doi:10.1016/S0006-291X(02)03073-5. PMID 12565893.

Further reading

• Schafer DA, Schroer TA (2000). "Actin-related proteins". Annu. Rev. Cell Dev. Biol. 15: 341–363. doi:10.1146/annurev.cellbio.15.1.341. PMID 10611965.
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Harata M, Mochizuki R, Mizuno S (1999). "Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues". Biosci. Biotechnol. Biochem. 63 (5): 917–923. doi:10.1271/bbb.63.917. PMID 10380635.
• Olave I, Wang W, Xue Y, Kuo A, Crabtree GR (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex". Genes Dev. 16 (19): 2509–2517. doi:10.1101/gad.992102. PMC 187451. PMID 12368262.
• Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M (2003). "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex". Biochem. Biophys. Res. Commun. 299 (2): 328–334. doi:10.1016/S0006-291X(02)02637-2. PMID 12437990.
• Oma Y, Nishimori K, Harata M (2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP". Biochem. Biophys. Res. Commun. 301 (2): 521–528. doi:10.1016/S0006-291X(02)03073-5. PMID 12565893.