ADM2

Adrenomedullin 2
Identifiers
Symbols	ADM2 ; AM2; dJ579N16.4
External IDs	OMIM: 608682 MGI: 2675256 HomoloGene: 49801 ChEMBL: 5267 GeneCards: ADM2 Gene
Gene ontology Molecular function • hormone activity • protein complex binding Cellular component • extracellular region Biological process • angiogenesis • protein phosphorylation • adenylate cyclase-activating G-protein coupled receptor signaling pathway • digestion • feeding behavior • positive regulation of gene expression • positive regulation of angiogenesis • negative regulation of blood pressure Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79924	223780
Ensembl	ENSG00000128165	ENSMUSG00000054136
UniProt	Q7Z4H4	Q7TNK8
RefSeq (mRNA)	NM_001253845	NM_182928
RefSeq (protein)	NP_001240774	NP_891558
Location (UCSC)	Chr 22: 50.48 – 50.49 Mb	Chr 15: 89.32 – 89.32 Mb
PubMed search

ADM2 is a protein that in humans is encoded by the ADM2 gene.^[1][2]

ADM2 belongs to a family of calcitonin (MIM 114130)-related peptide hormones important for regulating diverse physiologic functions and the chemical composition of fluids and tissues.[supplied by OMIM]^[2]

References

1. Takei Y, Inoue K, Ogoshi M, Kawahara T, Bannai H, Miyano S (Jan 2004). "Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator". FEBS Lett 556 (1–3): 53–8. doi:10.1016/S0014-5793(03)01368-1. PMID 14706825.
2. "Entrez Gene: ADM2 adrenomedullin 2".

Further reading

• Kawai M (2004). "[Diagnosis of dermatophytoses: conventional methods and recent molecular biological methods]". Nihon Ishinkin Gakkai zasshi (Japanese journal of medical mycology) 44 (4): 261–4. PMID 14615790.
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Roh J, Chang CL, Bhalla A; et al. (2004). "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes". J. Biol. Chem. 279 (8): 7264–74. doi:10.1074/jbc.M305332200. PMID 14615490.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Takahashi K, Kikuchi K, Maruyama Y; et al. (2006). "Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney". Peptides 27 (6): 1383–9. doi:10.1016/j.peptides.2005.11.004. PMID 16359754.
• Kindt F, Wiegand S, Löser C; et al. (2007). "Intermedin: a skin peptide that is downregulated in atopic dermatitis". J. Invest. Dermatol. 127 (3): 605–13. doi:10.1038/sj.jid.5700576. PMID 17008878.
• Morimoto R, Satoh F, Murakami O; et al. (2007). "Expression of adrenomedullin2/intermedin in human brain, heart, and kidney". Peptides 28 (5): 1095–103. doi:10.1016/j.peptides.2007.01.018. PMID 17346853.