AFF3

AF4/FMR2 family, member 3
Identifiers
Symbols	AFF3 ; LAF4; MLLT2-like
External IDs	OMIM: 601464 MGI: 106927 HomoloGene: 1718 GeneCards: AFF3 Gene
Gene ontology Molecular function • double-stranded DNA binding Cellular component • nucleus • nucleoplasm • cytoplasm Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • response to tumor necrosis factor • embryonic hindlimb morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3899	16764
Ensembl	ENSG00000144218	ENSMUSG00000037138
UniProt	P51826	P51827
RefSeq (mRNA)	NM_001025108	NM_001290814
RefSeq (protein)	NP_001020279	NP_001277743
Location (UCSC)	Chr 2: 99.55 – 100.14 Mb	Chr 1: 38.18 – 38.66 Mb
PubMed search

AF4/FMR2 family member 3 is a protein that in humans is encoded by the AFF3 gene.^[1][2][3]

Function

This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.^[3]

References

1. Liao X, Ma C, Trask B, Massa H, Gilbert DJ, Staudt LM, Jenkins NA, Copeland NG (Jun 1996). "LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12". Mammalian Genome 7 (6): 467–8. doi:10.1007/s003359900137. PMID 8662235.
2. Ma C, Staudt LM (Jan 1996). "LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias". Blood 87 (2): 734–45. PMID 8555498.
3. "Entrez Gene: AFF3 AF4/FMR2 family, member 3".

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• von Bergh AR, Beverloo HB, Rombout P, van Wering ER, van Weel MH, Beverstock GC, Kluin PM, Slater RM, Schuuring E (Sep 2002). "LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia". Genes, Chromosomes & Cancer 35 (1): 92–6. doi:10.1002/gcc.10091. PMID 12203795.
• Hiwatari M, Taki T, Taketani T, Taniwaki M, Sugita K, Okuya M, Eguchi M, Ida K, Hayashi Y (May 2003). "Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)". Oncogene 22 (18): 2851–5. doi:10.1038/sj.onc.1206389. PMID 12743608.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• To MD, Faseruk SA, Gokgoz N, Pinnaduwage D, Done SJ, Andrulis IL (Jul 2005). "LAF-4 is aberrantly expressed in human breast cancer". International Journal of Cancer. Journal International Du Cancer 115 (4): 568–74. doi:10.1002/ijc.20881. PMID 15704140.