AGPAT1

1-acylglycerol-3-phosphate O-acyltransferase 1
Identifiers
Symbols	AGPAT1 ; 1-AGPAT1; G15; LPAAT-alpha; LPAATA
External IDs	OMIM: 603099 MGI: 1932075 HomoloGene: 55973 ChEMBL: 3583 GeneCards: AGPAT1 Gene
EC number	2.3.1.51
Gene ontology Molecular function • 1-acylglycerol-3-phosphate O-acyltransferase activity • protein binding Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral component of membrane Biological process • positive regulation of cytokine production • positive regulation of cytokine-mediated signaling pathway • energy reserve metabolic process • phospholipid metabolic process • phosphatidic acid biosynthetic process • CDP-diacylglycerol biosynthetic process • triglyceride biosynthetic process • positive regulation of cellular metabolic process • cellular lipid metabolic process • small molecule metabolic process • glycerophospholipid biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10554	55979
Ensembl	ENSG00000204310	ENSMUSG00000034254
UniProt	Q99943	O35083
RefSeq (mRNA)	NM_006411	NM_001163379
RefSeq (protein)	NP_006402	NP_001156851
Location (UCSC)	Chr 6: 32.17 – 32.18 Mb	Chr 17: 34.6 – 34.61 Mb
PubMed search

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme that in humans is encoded by the AGPAT1 gene.^[1][2][3]

This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein.^[3]

References

1. Aguado B, Campbell RD (Mar 1998). "Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex". J Biol Chem 273 (7): 4096–105. doi:10.1074/jbc.273.7.4096. PMID 9461603.
2. Stamps AC, Elmore MA, Hill ME, Kelly K, Makda AA, Finnen MJ (Sep 1997). "A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases". Biochem J. 326. ( Pt 2): 455–61. PMC 1218691. PMID 9291118.
3. "Entrez Gene: AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)".

Further reading

• Leung DW (2001). "The structure and functions of human lysophosphatidic acid acyltransferases.". Front. Biosci. 6 (1): D944–53. doi:10.2741/Leung. PMID 11487472.
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• West J, Tompkins CK, Balantac N; et al. (1997). "Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells.". DNA Cell Biol. 16 (6): 691–701. doi:10.1089/dna.1997.16.691. PMID 9212163.
• Aguado B, Campbell RD (1998). "Human lysophosphatidic acid acyltransferase is encoded by a gene located in the major histocompatibility complex.". Biochem. Soc. Trans. 25 (4): S597. PMID 9450025.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Xie T, Rowen L, Aguado B; et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Servillo L, Balestrieri C, Giovane A; et al. (2006). "Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages.". FASEB J. 20 (7): 1015–7. doi:10.1096/fj.05-5059fje. PMID 16571775.
• Lloyd EE, Gaubatz JW, Burns AR, Pownall HJ (2007). "Sustained elevations in NEFA induce cyclooxygenase-2 activity and potentiate THP-1 macrophage foam cell formation.". Atherosclerosis 192 (1): 49–55. doi:10.1016/j.atherosclerosis.2006.06.014. PMID 16870193.