AIM1

Absent in melanoma 1
PDB rendering based on 2dad.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DAD​, 3CW3​
Identifiers
Symbols	AIM1 ; CRYBG1; ST4
External IDs	OMIM: 601797 MGI: 109544 HomoloGene: 18168 GeneCards: AIM1 Gene
Gene ontology Molecular function • molecular_function • carbohydrate binding Cellular component • cellular_component Biological process • biological_process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	202	11630
Ensembl	ENSG00000112297	ENSMUSG00000019866
UniProt	Q9Y4K1	E9PVP1
RefSeq (mRNA)	NM_001624	NM_172393
RefSeq (protein)	NP_001615	NP_765981
Location (UCSC)	Chr 6: 106.36 – 106.57 Mb	Chr 10: 43.95 – 44.15 Mb
PubMed search

Absent in melanoma 1 protein is a protein that in humans is encoded by the AIM1 gene.^[1][2][3]

References

1. Millikin D, Meese E, Vogelstein B, Witkowski C, Trent J (Nov 1991). "Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma". Cancer Res 51 (20): 5449–53. PMID 1680551.
2. Rajini B, Graham C, Wistow G, Sharma Y (Apr 2003). "Stability, homodimerization, and calcium-binding properties of a single, variant betagamma-crystallin domain of the protein absent in melanoma 1 (AIM1)". Biochemistry 42 (15): 4552–9. doi:10.1021/bi027384l. PMID 12693952.
3. "Entrez Gene: AIM1 absent in melanoma 1".

Further reading

• Ray ME, Su YA, Meltzer PS, Trent JM (1996). "Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma.". Oncogene 12 (12): 2527–33. PMID 8700511.
• Ray ME, Wistow G, Su YA; et al. (1997). "AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3229–34. doi:10.1073/pnas.94.7.3229. PMC 20351. PMID 9096375.
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Aravind P, Rajini B, Sharma Y, Sankaranarayanan R (2006). "Crystallization and preliminary X-ray crystallographic investigations on a betagamma-crystallin domain of absent in melanoma 1 (AIM1), a protein from Homo sapiens.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 (Pt 3): 282–4. doi:10.1107/S1744309106005380. PMC 2197174. PMID 16511323.