AKAP11

A kinase (PRKA) anchor protein 11
Identifiers
Symbols	AKAP11 ; AKAP-11; AKAP220; PPP1R44; PRKA11
External IDs	OMIM: 604696 MGI: 2684060 HomoloGene: 8279 GeneCards: AKAP11 Gene
Gene ontology Molecular function • protein phosphatase 1 binding • protein complex scaffold • protein kinase A catalytic subunit binding • protein kinase A regulatory subunit binding • protein kinase A binding Cellular component • cytoplasm • peroxisome • microtubule organizing center • protein complex Biological process • regulation of protein kinase A signaling • intracellular signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11215	219181
Ensembl	ENSG00000023516	ENSMUSG00000022016
UniProt	Q9UKA4	E9Q774
RefSeq (mRNA)	NM_016248	NM_001164503
RefSeq (protein)	NP_057332	NP_001157975
Location (UCSC)	Chr 13: 42.27 – 42.32 Mb	Chr 14: 78.49 – 78.54 Mb
PubMed search

A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene.^[1][2][3]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function.^[3]

Interactions

AKAP11 has been shown to interact with:

• GSK3B,^[4]
• PPP1CA,^[4][5]
• PRKAR2A,^[2][4][6] and
• PRKAR2B.^[7]

References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
2. Lester LB, Coghlan VM, Nauert B, Scott JD (June 1996). "Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes". J. Biol. Chem. 271 (16): 9460–5. doi:10.1074/jbc.271.16.9460. PMID 8621616.
3. "Entrez Gene: AKAP11 A kinase (PRKA) anchor protein 11".
4. Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A (October 2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40): 36955–61. doi:10.1074/jbc.M206210200. PMID 12147701.
5. Schillace RV, Scott JD (March 1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. doi:10.1016/S0960-9822(99)80141-9. PMID 10209101.
6. Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (April 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
7. Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (July 2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Dev. Biol. 223 (1): 194–204. doi:10.1006/dbio.2000.9725. PMID 10864471.

Further reading

• Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29; discussion 429–30. PMID 9238861.
• Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Schillace RV, Scott JD (1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. doi:10.1016/S0960-9822(99)80141-9. PMID 10209101.
• Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Dev. Biol. 223 (1): 194–204. doi:10.1006/dbio.2000.9725. PMID 10864471.
• Schillace RV, Voltz JW, Sim AT, Shenolikar S, Scott JD (2001). "Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation". J. Biol. Chem. 276 (15): 12128–34. doi:10.1074/jbc.M010398200. PMID 11152471.
• Schillace RV, Andrews SF, Liberty GA, Davey MP, Carr DW (2002). "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes". J. Immunol. 168 (4): 1590–9. doi:10.4049/jimmunol.168.4.1590. PMID 11823486.
• Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A (2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40): 36955–61. doi:10.1074/jbc.M206210200. PMID 12147701.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.