AKAP7

A kinase (PRKA) anchor protein 7
Identifiers
Symbols	AKAP7 ; AKAP15; AKAP18
External IDs	OMIM: 604693 MGI: 1859150 HomoloGene: 49463 GeneCards: AKAP7 Gene
Gene ontology Molecular function • nucleotide binding • protein binding • protein kinase binding • protein kinase A regulatory subunit binding • protein kinase A binding Cellular component • intracellular • nucleus • cytosol • plasma membrane • apical plasma membrane • lateral plasma membrane Biological process • action potential • ion transport • protein localization • biological_process • intracellular signal transduction • regulation of membrane repolarization • cellular response to cAMP • positive regulation of potassium ion transmembrane transport • positive regulation of delayed rectifier potassium channel activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9465	432442
Ensembl	ENSG00000118507	ENSMUSG00000039166
UniProt	O43687	O55074
RefSeq (mRNA)	NM_004842	NM_018747
RefSeq (protein)	NP_004833	NP_061217
Location (UCSC)	Chr 6: 131.14 – 131.28 Mb	Chr 10: 25.17 – 25.31 Mb
PubMed search

A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene.^[1][2]

Function

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.^[2]

References

1. Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD (Apr 1998). "A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events". The EMBO Journal 17 (8): 2261–2272. doi:10.1093/emboj/17.8.2261. PMC 1170570. PMID 9545239.
2. "Entrez Gene: AKAP7 A kinase (PRKA) anchor protein 7".

Further reading

• Gold MG, Smith FD, Scott JD, Barford D (Feb 2008). "AKAP18 contains a phosphoesterase domain that binds AMP". Journal of Molecular Biology 375 (5): 1329–1343. doi:10.1016/j.jmb.2007.11.037. PMC 3188456. PMID 18082768.
• Bengrine A, Li J, Awayda MS (Apr 2007). "The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel". FASEB Journal 21 (4): 1189–1201. doi:10.1096/fj.06-6046com. PMID 17244820.
• Brown RL, August SL, Williams CJ, Moss SB (Jun 2003). "AKAP7gamma is a nuclear RI-binding AKAP". Biochemical and Biophysical Research Communications 306 (2): 394–401. doi:10.1016/S0006-291X(03)00982-3. PMID 12804576.
• Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proceedings of the National Academy of Sciences of the United States of America 100 (8): 4445–4450. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
• Trotter KW, Fraser ID, Scott GK, Stutts MJ, Scott JD, Milgram SL (Dec 1999). "Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms". The Journal of Cell Biology 147 (7): 1481–1492. doi:10.1083/jcb.147.7.1481. PMC 2174236. PMID 10613906.