AKAP8L

A kinase (PRKA) anchor protein 8-like
Identifiers
Symbols AKAP8L ; HA95; HAP95; NAKAP; NAKAP95
External IDs OMIM: 609475 MGI: 1860606 HomoloGene: 8658 GeneCards: AKAP8L Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 26993 54194
Ensembl ENSG00000011243 ENSMUSG00000002625
UniProt Q9ULX6 Q5RL57
RefSeq (mRNA) NM_001291478 NM_017476
RefSeq (protein) NP_001278407 NP_059504
Location (UCSC) Chr 19:
15.38 – 15.42 Mb		 Chr 17:
32.32 – 32.35 Mb
PubMed search

A-kinase anchor protein 8-like is a protein that in humans is encoded by the AKAP8L gene.[1][2][3]

Interactions

AKAP8L has been shown to interact with:

References

  1. 1 2 Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F (Jul 2000). "A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element". The Journal of Biological Chemistry 275 (28): 21396–21401. doi:10.1074/jbc.M909887199. PMID 10748171.
  2. ↑ Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS (Jan 2000). "Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95". Biology of the Cell / Under the Auspices of the European Cell Biology Organization 92 (1): 27–37. doi:10.1016/S0248-4900(00)88761-4. PMID 10761695.
  3. ↑ "Entrez Gene: AKAP8L A kinase (PRKA) anchor protein 8-like".
  4. ↑ Yang JP, Tang H, Reddy TR, Wong-Staal F (Aug 2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses". The Journal of Biological Chemistry 276 (33): 30694–700. doi:10.1074/jbc.M102809200. PMID 11402034.
  5. ↑ Martins SB, Eide T, Steen RL, Jahnsen T, Skålhegg BS, Collas P (Nov 2000). "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics". Journal of Cell Science. 113 Pt 21: 3703–13. PMID 11034899.
  6. ↑ Martins S, Eikvar S, Furukawa K, Collas P (Jan 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". The Journal of Cell Biology 160 (2): 177–88. doi:10.1083/jcb.200210026. PMC 2172640. PMID 12538639.

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Dec 1998). "Selection system for genes encoding nuclear-targeted proteins". Nature Biotechnology 16 (13): 1338–1342. doi:10.1038/4315. PMID 9853615. 
  • Seki N, Ueki N, Yano K, Saito T, Masuho Y, Muramatsu M (2000). "cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region". Journal of Human Genetics 45 (1): 0031–0037. doi:10.1007/s100380070040. PMID 10697960. 
  • Yang JP, Tang H, Reddy TR, Wong-Staal F (Aug 2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses". The Journal of Biological Chemistry 276 (33): 30694–30700. doi:10.1074/jbc.M102809200. PMID 11402034. 
  • Wistow G, Bernstein SL, Ray S, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Molecular Vision 8: 185–95. PMID 12107412. 
  • Martins S, Eikvar S, Furukawa K, Collas P (Jan 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". The Journal of Cell Biology 160 (2): 177–188. doi:10.1083/jcb.200210026. PMC 2172640. PMID 12538639. 
  • Martins SB, Marstad A, Collas P (Sep 2003). "In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling". Biochemistry 42 (35): 10456–10461. doi:10.1021/bi0350699. PMID 12950172. 
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. 
  • Sayer JA, Manczak M, Akileswaran L, Reddy PH, Coghlan VM (2006). "Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis". Neuromolecular Medicine 7 (4): 297–310. doi:10.1385/NMM:7:4:297. PMID 16391387. 


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